The Masonic Medical Research Laboratory (MMRL) is an internationally recognized biomedical research institute. For its size, there are few institutes worldwide whose cutting edge research is as productive and influential in the field of experimental cardiology. In recent years, the MMRL has become an international center for genetic screening of cardiac arrhythmia diseases, especially those contributing to sudden death syndromes, including sudden infant death syndrome (SIDS). The MMRL is blazing new trails in the development of safe and effective drugs for atrial fibrillation, addressing one of the greatest unmet medical needs facing our society. With its recent inauguration of a Stem Cell Center, the MMRL is making rapid progress in the creation of human models of disease focused on development of innovative therapies and cures.