Scientific Publications

Written by on October 26, 2018 in Publications

Click below to access scholarly publications that report original empirical and theoretical work done at the Masonic Medical Research Institute.

  1. Shiferaw, Y, Aistrup, GL, Louch, WE, Wasserstrom, JA. Remodeling Promotes Proarrhythmic Disruption of Calcium Homeostasis in Failing Atrial Myocytes. Biophys. J. 2019; :. doi: 10.1016/j.bpj.2019.12.012. PubMed PMID:31889516 .
  2. Chen, J, Ma, Q, King, JS, Sun, Y, Xu, B, Zhang, X et al.. aYAP modRNA reduces cardiac inflammation and hypertrophy in a murine ischemia-reperfusion model. Life Sci Alliance. 2020;3 (1):. doi: 10.26508/lsa.201900424. PubMed PMID:31843959 PubMed Central PMC6918510.
  3. Gripp, KW, Schill, L, Schoyer, L, Stronach, B, Bennett, AM, Blaser, S et al.. The sixth international RASopathies symposium: Precision medicine-From promise to practice. Am. J. Med. Genet. A. 2019; :. doi: 10.1002/ajmg.a.61434. PubMed PMID:31825160 .
  4. Perenthaler, E, Nikoncuk, A, Yousefi, S, Berdowski, WM, Alsagob, M, Capo, I et al.. Loss of UGP2 in brain leads to a severe epileptic encephalopathy, emphasizing that bi-allelic isoform-specific start-loss mutations of essential genes can cause genetic diseases. Acta Neuropathol. 2019; :. doi: 10.1007/s00401-019-02109-6. PubMed PMID:31820119 .
  5. Gussak, G, Pfenniger, A, Wren, L, Gilani, M, Zhang, W, Yoo, S et al.. Region-specific parasympathetic nerve remodeling in the left atrium contributes to creation of a vulnerable substrate for atrial fibrillation. JCI Insight. 2019;4 (20):. doi: 10.1172/jci.insight.130532. PubMed PMID:31503549 PubMed Central PMC6824299.
  6. Treat, JA, Goodrow, RJ, Bot, CT, Haedo, RJ, Cordeiro, JM. Pharmacological enhancement of repolarization reserve in human induced pluripotent stem cells derived cardiomyocytes. Biochem. Pharmacol. 2019;169 :113608. doi: 10.1016/j.bcp.2019.08.010. PubMed PMID:31465775 .
  7. Pathmanathan, P, Cordeiro, JM, Gray, RA. Comprehensive Uncertainty Quantification and Sensitivity Analysis for Cardiac Action Potential Models. Front Physiol. 2019;10 :721. doi: 10.3389/fphys.2019.00721. PubMed PMID:31297060 PubMed Central PMC6607060.
  8. Jaffré, F, Miller, CL, Schänzer, A, Evans, T, Roberts, AE, Hahn, A et al.. Inducible Pluripotent Stem Cell-Derived Cardiomyocytes Reveal Aberrant Extracellular Regulated Kinase 5 and Mitogen-Activated Protein Kinase Kinase 1/2 Signaling Concomitantly Promote Hypertrophic Cardiomyopathy in RAF1-Associated Noonan Syndrome. Circulation. 2019;140 (3):207-224. doi: 10.1161/CIRCULATIONAHA.118.037227. PubMed PMID:31163979 PubMed Central PMC6709678.
  9. Yu, W, Ma, X, Xu, J, Heumüller, AW, Fei, Z, Feng, X et al.. VGLL4 plays a critical role in heart valve development and homeostasis. PLoS Genet. 2019;15 (2):e1007977. doi: 10.1371/journal.pgen.1007977. PubMed PMID:30789911 PubMed Central PMC6400400.
  10. Lux, JC, Channaveerappa, D, Aslebagh, R, Heintz, TA, McLerie, M, Panama, BK et al.. Identification of dysregulation of atrial proteins in rats with chronic obstructive apnea using two-dimensional polyacrylamide gel electrophoresis and mass spectrometry. J. Cell. Mol. Med. 2019;23 (4):3016-3020. doi: 10.1111/jcmm.14131. PubMed PMID:30756508 PubMed Central PMC6433690.
  11. Tümüklü, MN, Tümüklü, MM, Nesterenko, V, Jayathilake, K, Beasley, CM Jr, Meltzer, HY et al.. Twenty-Four-Hour Measures of Heart Rate-Corrected QT Interval, Peak-to-End of the T-Wave, and Peak-to-End of the T-Wave/Corrected QT Interval Ratio During Antipsychotic Treatment. J Clin Psychopharmacol. ;39 (2):100-107. doi: 10.1097/JCP.0000000000001003. PubMed PMID:30707117 .
  12. Li, R, Baskfield, A, Lin, Y, Beers, J, Zou, J, Liu, C et al.. Generation of an induced pluripotent stem cell line (TRNDi003-A) from a Noonan syndrome with multiple lentigines (NSML) patient carrying a p.Q510P mutation in the PTPN11 gene. Stem Cell Res. 2019;34 :101374. doi: 10.1016/j.scr.2018.101374. PubMed PMID:30640061 .
  13. Yoon, N, Patocskai, B, Antzelevitch, C. Epicardial Substrate as a Target for Radiofrequency Ablation in an Experimental Model of Early Repolarization Syndrome. Circ Arrhythm Electrophysiol. 2018;11 (9):e006511. doi: 10.1161/CIRCEP.118.006511. PubMed PMID:30354293 .
  14. Sicouri, S, Belardinelli, L, Antzelevitch, C. Effect of autonomic influences to induce triggered activity in muscular sleeves extending into the coronary sinus of the canine heart and its suppression by ranolazine. J. Cardiovasc. Electrophysiol. 2019;30 (2):230-238. doi: 10.1111/jce.13770. PubMed PMID:30302862 .
  15. Yuan, M, Tian, C, Li, X, Yang, X, Wang, X, Yang, Y et al.. Gender Differences in Prognosis and Risk Stratification of Brugada Syndrome: A Pooled Analysis of 4,140 Patients From 24 Clinical Trials. Front Physiol. 2018;9 :1127. doi: 10.3389/fphys.2018.01127. PubMed PMID:30246798 PubMed Central PMC6113678.
  16. Shiferaw, Y, Aistrup, GL, Wasserstrom, JA. Synchronization of Triggered Waves in Atrial Tissue. Biophys. J. 2018;115 (6):1130-1141. doi: 10.1016/j.bpj.2018.08.015. PubMed PMID:30195941 PubMed Central PMC6139957.
  17. Calloe, K, Aistrup, GL, Di Diego, JM, Goodrow, RJ, Treat, JA, Cordeiro, JM et al.. Interventricular differences in sodium current and its potential role in Brugada syndrome. Physiol Rep. 2018;6 (14):e13787. doi: 10.14814/phy2.13787. PubMed PMID:30009404 PubMed Central PMC6046646.
  18. Hu, D, Li, Y, Zhang, J, Pfeiffer, R, Gollob, MH, Healey, J et al.. The Phenotypic Spectrum of a Mutation Hotspot Responsible for the Short QT Syndrome. JACC Clin Electrophysiol. 2017;3 (7):727-743. doi: 10.1016/j.jacep.2016.11.013. PubMed PMID:29759541 .
  19. Xu, G, Gottschalk, BH, Anselm, DD, Benditt, DG, Maheshwari, A, Sreenivasan, S et al.. Relation of the Brugada Phenocopy to Hyperkalemia (from the International Registry on Brugada Phenocopy). Am. J. Cardiol. 2018;121 (6):715-717. doi: 10.1016/j.amjcard.2017.12.008. PubMed PMID:29397883 .
  20. Baker, CE, Moore-Lotridge, SN, Hysong, AA, Posey, SL, Robinette, JP, Blum, DM et al.. Bone Fracture Acute Phase Response-A Unifying Theory of Fracture Repair: Clinical and Scientific Implications. Clin Rev Bone Miner Metab. 2018;16 (4):142-158. doi: 10.1007/s12018-018-9256-x. PubMed PMID:30930699 PubMed Central PMC6404386.
  21. Li, Y, Zhang, Z, Xiong, X, Cho, WC, Hu, D, Gao, Y et al.. Immediate/Early vs. Delayed Invasive Strategy for Patients with Non-ST-Segment Elevation Acute Coronary Syndromes: A Systematic Review and Meta-Analysis. Front Physiol. 2017;8 :952. doi: 10.3389/fphys.2017.00952. PubMed PMID:29230180 PubMed Central PMC5712112.
  22. Shi, S, Barajas-Martinez, H, Liu, T, Sun, Y, Yang, B, Huang, C et al.. Prevalence of spontaneous Brugada ECG pattern recorded at standard intercostal leads: A meta-analysis. Int. J. Cardiol. 2018;254 :151-156. doi: 10.1016/j.ijcard.2017.11.113. PubMed PMID:29224924 .
  23. Goodrow, RJ Jr, Desai, S, Treat, JA, Panama, BK, Desai, M, Nesterenko, VV et al.. Biophysical comparison of sodium currents in native cardiac myocytes and human induced pluripotent stem cell-derived cardiomyocytes. J Pharmacol Toxicol Methods. ;90 :19-30. doi: 10.1016/j.vascn.2017.11.001. PubMed PMID:29128504 .
  24. Aistrup, GL, Arora, R, Grubb, S, Yoo, S, Toren, B, Kumar, M et al.. Triggered intracellular calcium waves in dog and human left atrial myocytes from normal and failing hearts. Cardiovasc. Res. 2017;113 (13):1688-1699. doi: 10.1093/cvr/cvx167. PubMed PMID:29016724 PubMed Central PMC5852523.
  25. Patocskai, B, Yoon, N, Antzelevitch, C. Mechanisms Underlying Epicardial Radiofrequency Ablation to Suppress Arrhythmogenesis in Experimental Models of Brugada Syndrome. JACC Clin Electrophysiol. 2017;3 (4):353-363. doi: 10.1016/j.jacep.2016.10.011. PubMed PMID:28948234 PubMed Central PMC5609479.
  26. Li, J, Li, Y, Zhang, Y, Hu, D, Gao, Y, Shang, H et al.. The Inhibitory Effect of WenxinKeli on H9C2 Cardiomyocytes Hypertrophy Induced by Angiotensin II through Regulating Autophagy Activity. Oxid Med Cell Longev. 2017;2017 :7042872. doi: 10.1155/2017/7042872. PubMed PMID:28713489 PubMed Central PMC5496123.
  27. Wang, X, Hu, D, Dang, S, Huang, H, Huang, CX, Yuan, MJ et al.. Effects of Traditional Chinese Medicine Shensong Yangxin Capsules on Heart Rhythm and Function in Congestive Heart Failure Patients with Frequent Ventricular Premature Complexes: A Randomized, Double-blind, Multicenter Clinical Trial. Chin. Med. J. 2017;130 (14):1639-1647. doi: 10.4103/0366-6999.209906. PubMed PMID:28685712 PubMed Central PMC5520549.
  28. Makarawate, P, Chaosuwannakit, N, Vannaprasaht, S, Sahasthas, D, Koo, SH, Lee, EJD et al.. SCN5A Genetic Polymorphisms Associated With Increased Defibrillator Shocks in Brugada Syndrome. J Am Heart Assoc. 2017;6 (6):. doi: 10.1161/JAHA.116.005009. PubMed PMID:28584071 PubMed Central PMC5669154.
  29. Li, J, Hu, D, Song, X, Han, T, Gao, Y, Xing, Y et al.. The Role of Biologically Active Ingredients from Natural Drug Treatments for Arrhythmias in Different Mechanisms. Biomed Res Int. 2017;2017 :4615727. doi: 10.1155/2017/4615727. PubMed PMID:28497050 PubMed Central PMC5405360.
  30. Shi, S, Liu, T, Barajas-Martinez, H, Pfeiffer, R, Jiang, H, Huang, C et al.. Atrial fibrillation associated with Wolff-Parkinson-White syndrome in a patient with concomitant Brugada syndrome. HeartRhythm Case Rep. 2017;3 (1):13-17. doi: 10.1016/j.hrcr.2016.12.001. PubMed PMID:28491758 PubMed Central PMC5420038.
  31. Chen, Y, Barajas-Martinez, H, Zhu, D, Wang, X, Chen, C, Zhuang, R et al.. Erratum to: Novel trigenic CACNA1C/DES/MYPN mutations in a family of hypertrophic cardiomyopathy with early repolarization and short QT syndrome. J Transl Med. 2017;15 (1):101. doi: 10.1186/s12967-017-1203-y. PubMed PMID:28490369 PubMed Central PMC5425985.
  32. Chen, Y, Barajas-Martinez, H, Zhu, D, Wang, X, Chen, C, Zhuang, R et al.. Novel trigenic CACNA1C/DES/MYPN mutations in a family of hypertrophic cardiomyopathy with early repolarization and short QT syndrome. J Transl Med. 2017;15 (1):78. doi: 10.1186/s12967-017-1180-1. PubMed PMID:28427417 PubMed Central PMC5399316.
  33. Channaveerappa, D, Lux, JC, Wormwood, KL, Heintz, TA, McLerie, M, Treat, JA et al.. Atrial electrophysiological and molecular remodelling induced by obstructive sleep apnoea. J. Cell. Mol. Med. 2017;21 (9):2223-2235. doi: 10.1111/jcmm.13145. PubMed PMID:28402037 PubMed Central PMC5571519.
  34. Yu, L, Wang, M, Hu, D, Huang, B, Zhou, L, Zhou, X et al.. Blocking the Nav1.8 channel in the left stellate ganglion suppresses ventricular arrhythmia induced by acute ischemia in a canine model. Sci Rep. 2017;7 (1):534. doi: 10.1038/s41598-017-00642-6. PubMed PMID:28373696 PubMed Central PMC5428783.
  35. Barajas-Martinez, H, Goodrow, RJ, Hu, D, Patel, P, Desai, M, Panama, BK et al.. Biophysical and molecular comparison of sodium current in cells isolated from canine atria and pulmonary vein. Pflugers Arch. 2017;469 (5-6):703-712. doi: 10.1007/s00424-017-1956-4. PubMed PMID:28243733 .
  36. Feng, Y, Liu, J, Wang, M, Liu, M, Shi, L, Yuan, W et al.. The E23K variant of the Kir6.2 subunit of the ATP-sensitive potassium channel increases susceptibility to ventricular arrhythmia in response to ischemia in rats. Int. J. Cardiol. 2017;232 :192-198. doi: 10.1016/j.ijcard.2017.01.022. PubMed PMID:28082085 .
  37. Chen, X, Yu, L, Shi, S, Jiang, H, Huang, C, Desai, M et al.. Neuronal Nav1.8 Channels as a Novel Therapeutic Target of Acute Atrial Fibrillation Prevention. J Am Heart Assoc. 2016;5 (11):. doi: 10.1161/JAHA.116.004050. PubMed PMID:27806967 PubMed Central PMC5210368.
  38. Dai, M, Bao, M, Zhang, Y, Yu, L, Cao, Q, Tang, Y et al.. Low-level carotid baroreflex stimulation suppresses atrial fibrillation by inhibiting left stellate ganglion activity in an acute canine model. Heart Rhythm. 2016;13 (11):2203-2212. doi: 10.1016/j.hrthm.2016.08.021. PubMed PMID:27520541 .
  39. Chorin, E, Hu, D, Antzelevitch, C, Hochstadt, A, Belardinelli, L, Zeltser, D et al.. Ranolazine for Congenital Long-QT Syndrome Type III: Experimental and Long-Term Clinical Data. Circ Arrhythm Electrophysiol. 2016;9 (10):. doi: 10.1161/CIRCEP.116.004370. PubMed PMID:27733495 PubMed Central PMC5119553.
  40. Yang, M, Zhang, GG, Wang, T, Wang, X, Tang, YH, Huang, H et al.. TBX18 gene induces adipose-derived stem cells to differentiate into pacemaker-like cells in the myocardial microenvironment. Int. J. Mol. Med. 2016;38 (5):1403-1410. doi: 10.3892/ijmm.2016.2736. PubMed PMID:27632938 PubMed Central PMC5065308.
  41. Shi, S, Liu, T, Liang, J, Hu, D, Yang, B. Depression and Risk of Sudden Cardiac Death and Arrhythmias: A Meta-Analysis. Psychosom Med. ;79 (2):153-161. doi: 10.1097/PSY.0000000000000382. PubMed PMID:27627224 .
  42. Huang, Y, Wang, D, Wang, X, Zhang, Y, Liu, T, Chen, Y et al.. Abrogation of CC chemokine receptor 9 ameliorates ventricular remodeling in mice after myocardial infarction. Sci Rep. 2016;6 :32660. doi: 10.1038/srep32660. PubMed PMID:27585634 PubMed Central PMC5009347.
  43. Veltmann, C, Barajas-Martinez, H, Wolpert, C, Borggrefe, M, Schimpf, R, Pfeiffer, R et al.. Further Insights in the Most Common SCN5A Mutation Causing Overlapping Phenotype of Long QT Syndrome, Brugada Syndrome, and Conduction Defect. J Am Heart Assoc. 2016;5 (7):. doi: 10.1161/JAHA.116.003379. PubMed PMID:27381756 PubMed Central PMC5015375.
  44. Sutphin, BS, Boczek, NJ, Barajas-Martínez, H, Hu, D, Ye, D, Tester, DJ et al.. Molecular and Functional Characterization of Rare CACNA1C Variants in Sudden Unexplained Death in the Young. Congenit Heart Dis. 2016;11 (6):683-692. doi: 10.1111/chd.12371. PubMed PMID:27218670 .
  45. Shi, S, Liu, T, Wang, D, Zhang, Y, Liang, J, Yang, B et al.. Activation of N-methyl-d-aspartate receptors reduces heart rate variability and facilitates atrial fibrillation in rats. Europace. 2017;19 (7):1237-1243. doi: 10.1093/europace/euw086. PubMed PMID:27170002 .
  46. Mizusawa, Y, Morita, H, Adler, A, Havakuk, O, Thollet, A, Maury, P et al.. Prognostic significance of fever-induced Brugada syndrome. Heart Rhythm. 2016;13 (7):1515-20. doi: 10.1016/j.hrthm.2016.03.044. PubMed PMID:27033637 .
  47. Calloe, K, Di Diego, JM, Hansen, RS, Nagle, SA, Treat, JA, Cordeiro, JM et al.. A dual potassium channel activator improves repolarization reserve and normalizes ventricular action potentials. Biochem. Pharmacol. 2016;108 :36-46. doi: 10.1016/j.bcp.2016.03.015. PubMed PMID:27002181 .
  48. Wang, D, Liu, T, Shi, S, Li, R, Shan, Y, Huang, Y et al.. Chronic Administration of Catestatin Improves Autonomic Function and Exerts Cardioprotective Effects in Myocardial Infarction Rats. J. Cardiovasc. Pharmacol. Ther. 2016;21 (6):526-535. doi: 10.1177/1074248416628676. PubMed PMID:26821570 .
  49. Patocskai, B, Barajas-Martinez, H, Hu, D, Gurabi, Z, Koncz, I, Antzelevitch, C et al.. Cellular and ionic mechanisms underlying the effects of cilostazol, milrinone, and isoproterenol to suppress arrhythmogenesis in an experimental model of early repolarization syndrome. Heart Rhythm. 2016;13 (6):1326-34. doi: 10.1016/j.hrthm.2016.01.024. PubMed PMID:26820510 PubMed Central PMC4879023.
  50. Hu, D, Barajas-Martínez, H, Burashnikov, A, Panama, BK, Cordeiro, JM, Antzelevitch, C et al.. Mechanisms underlying atrial-selective block of sodium channels by Wenxin Keli: Experimental and theoretical analysis. Int. J. Cardiol. 2016;207 :326-34. doi: 10.1016/j.ijcard.2016.01.016. PubMed PMID:26820362 PubMed Central PMC4758862.
  51. Panama, BK, Korogyi, AS, Aschar-Sobbi, R, Oh, Y, Gray, CB, Gang, H et al.. Reductions in the Cardiac Transient Outward K+ Current Ito Caused by Chronic β-Adrenergic Receptor Stimulation Are Partly Rescued by Inhibition of Nuclear Factor κB. J. Biol. Chem. 2016;291 (8):4156-65. doi: 10.1074/jbc.M115.694984. PubMed PMID:26742842 PubMed Central PMC4759190.
  52. Cordeiro, JM, Calloe, K, Aschar-Sobbi, R, Kim, KH, Korogyi, A, Occhipinti, D et al.. Physiological roles of the transient outward current Ito in normal and diseased hearts. Front Biosci (Schol Ed). 2016;8 :143-59. doi: 10.2741/s454. PubMed PMID:26709904 .
  53. Xing, Y, Hu, D, Zhang, T, Antzelevitch, C. Traditional Chinese Medicine and Vascular Disease. Evid Based Complement Alternat Med. 2015;2015 :430818. doi: 10.1155/2015/430818. PubMed PMID:26576194 PubMed Central PMC4631889.
  54. Hasdemir, C, Payzin, S, Kocabas, U, Sahin, H, Yildirim, N, Alp, A et al.. High prevalence of concealed Brugada syndrome in patients with atrioventricular nodal reentrant tachycardia. Heart Rhythm. 2015;12 (7):1584-94. doi: 10.1016/j.hrthm.2015.03.015. PubMed PMID:25998140 .
  55. Cordeiro, JM, Zeina, T, Goodrow, R, Kaplan, AD, Thomas, LM, Nesterenko, VV et al.. Regional variation of the inwardly rectifying potassium current in the canine heart and the contributions to differences in action potential repolarization. J. Mol. Cell. Cardiol. 2015;84 :52-60. doi: 10.1016/j.yjmcc.2015.04.010. PubMed PMID:25889894 PubMed Central PMC4468020.
  56. Giustetto, C, Scrocco, C, Schimpf, R, Maury, P, Mazzanti, A, Levetto, M et al.. Usefulness of exercise test in the diagnosis of short QT syndrome. Europace. 2015;17 (4):628-34. doi: 10.1093/europace/euu351. PubMed PMID:25833882 .
  57. Tan, BY, Yong, RY, Barajas-Martinez, H, Dumaine, R, Chew, YX, Wasan, PS et al.. A Brugada syndrome proband with compound heterozygote SCN5A mutations identified from a Chinese family in Singapore. Europace. 2016;18 (6):897-904. doi: 10.1093/europace/euv058. PubMed PMID:25829473 .
  58. Liang, J, Yuan, X, Shi, S, Wang, F, Chen, Y, Qu, C et al.. Effect and mechanism of fluoxetine on electrophysiology in vivo in a rat model of postmyocardial infarction depression. Drug Des Devel Ther. 2015;9 :763-72. doi: 10.2147/DDDT.S75863. PubMed PMID:25709400 PubMed Central PMC4330040.
  59. Obeyesekere, MN, Antzelevitch, C, Krahn, AD. Management of ventricular arrhythmias in suspected channelopathies. Circ Arrhythm Electrophysiol. 2015;8 (1):221-31. doi: 10.1161/CIRCEP.114.002321. PubMed PMID:25691556 .
  60. Pathmanathan, P, Shotwell, MS, Gavaghan, DJ, Cordeiro, JM, Gray, RA. Uncertainty quantification of fast sodium current steady-state inactivation for multi-scale models of cardiac electrophysiology. Prog. Biophys. Mol. Biol. 2015;117 (1):4-18. doi: 10.1016/j.pbiomolbio.2015.01.008. PubMed PMID:25661325 PubMed Central PMC4472478.
  61. Burashnikov, A, Di Diego, JM, Goodrow, RJ Jr, Belardinelli, L, Antzelevitch, C. Atria are More Sensitive Than Ventricles to GS-458967-Induced Inhibition of Late Sodium Current. J. Cardiovasc. Pharmacol. Ther. 2015;20 (5):501-8. doi: 10.1177/1074248415570636. PubMed PMID:25652294 .
  62. Burashnikov, A, Belardinelli, L, Antzelevitch, C. Inhibition of IKr potentiates development of atrial-selective INa block leading to effective suppression of atrial fibrillation. Heart Rhythm. 2015;12 (4):836-44. doi: 10.1016/j.hrthm.2014.12.033. PubMed PMID:25546810 .
  63. Maleckar, MM, Lines, GT, Koivumäki, JT, Cordeiro, JM, Calloe, K. NS5806 partially restores action potential duration but fails to ameliorate calcium transient dysfunction in a computational model of canine heart failure. Europace. 2014;16 Suppl 4 :iv46-iv55. doi: 10.1093/europace/euu252. PubMed PMID:25362170 .
  64. Boczek, NJ, Miller, EM, Ye, D, Nesterenko, VV, Tester, DJ, Antzelevitch, C et al.. Novel Timothy syndrome mutation leading to increase in CACNA1C window current. Heart Rhythm. 2015;12 (1):211-9. doi: 10.1016/j.hrthm.2014.09.051. PubMed PMID:25260352 PubMed Central PMC4907369.
  65. Hennessey, JA, Boczek, NJ, Jiang, YH, Miller, JD, Patrick, W, Pfeiffer, R et al.. A CACNA1C variant associated with reduced voltage-dependent inactivation, increased CaV1.2 channel window current, and arrhythmogenesis. PLoS ONE. 2014;9 (9):e106982. doi: 10.1371/journal.pone.0106982. PubMed PMID:25184293 PubMed Central PMC4153713.
  66. Shi, S, Liang, J, Liu, T, Yuan, X, Ruan, B, Sun, L et al.. Depression increases sympathetic activity and exacerbates myocardial remodeling after myocardial infarction: evidence from an animal experiment. PLoS ONE. 2014;9 (7):e101734. doi: 10.1371/journal.pone.0101734. PubMed PMID:25036781 PubMed Central PMC4103791.
  67. Hu, D, Barajas-Martínez, H, Pfeiffer, R, Dezi, F, Pfeiffer, J, Buch, T et al.. Mutations in SCN10A are responsible for a large fraction of cases of Brugada syndrome. J. Am. Coll. Cardiol. 2014;64 (1):66-79. doi: 10.1016/j.jacc.2014.04.032. PubMed PMID:24998131 PubMed Central PMC4116276.
  68. Burashnikov, A, Di Diego, JM, Barajas-Martínez, H, Hu, D, Zygmunt, AC, Cordeiro, JM et al.. Ranolazine effectively suppresses atrial fibrillation in the setting of heart failure. Circ Heart Fail. 2014;7 (4):627-33. doi: 10.1161/CIRCHEARTFAILURE.114.001129. PubMed PMID:24874201 PubMed Central PMC4102661.
  69. Tülümen, E, Giustetto, C, Wolpert, C, Maury, P, Anttonen, O, Probst, V et al.. Reply to the Editor--PQ-segment depression in short QT syndrome patients: a novel marker for diagnosing short QT syndrome?. Heart Rhythm. 2014;11 (7):e8. doi: 10.1016/j.hrthm.2014.04.028. PubMed PMID:24768854 .
  70. Di Diego, JM, Antzelevitch, C. Acute myocardial ischemia: cellular mechanisms underlying ST segment elevation. J Electrocardiol. ;47 (4):486-90. doi: 10.1016/j.jelectrocard.2014.02.005. PubMed PMID:24742586 PubMed Central PMC4116460.
  71. Antzelevitch, C, Nesterenko, V, Shryock, JC, Rajamani, S, Song, Y, Belardinelli, L et al.. The role of late I Na in development of cardiac arrhythmias. Handb Exp Pharmacol. 2014;221 :137-68. doi: 10.1007/978-3-642-41588-3_7. PubMed PMID:24737235 PubMed Central PMC4076160.
  72. Szél, T, Antzelevitch, C. Abnormal repolarization as the basis for late potentials and fractionated electrograms recorded from epicardium in experimental models of Brugada syndrome. J. Am. Coll. Cardiol. 2014;63 (19):2037-45. doi: 10.1016/j.jacc.2014.01.067. PubMed PMID:24657694 PubMed Central PMC4024366.
  73. Tülümen, E, Giustetto, C, Wolpert, C, Maury, P, Anttonen, O, Probst, V et al.. PQ segment depression in patients with short QT syndrome: a novel marker for diagnosing short QT syndrome?. Heart Rhythm. 2014;11 (6):1024-30. doi: 10.1016/j.hrthm.2014.02.024. PubMed PMID:24589867 PubMed Central PMC4108989.
  74. Burashnikov, A, Di Diego, JM, Sicouri, S, Doss, MX, Sachinidis, A, Barajas-Martínez, H et al.. A temporal window of vulnerability for development of atrial fibrillation with advancing heart failure. Eur. J. Heart Fail. 2014;16 (3):271-80. doi: 10.1002/ejhf.28. PubMed PMID:24464846 .
  75. Hu, D, Barajas-Martínez, H, Terzic, A, Park, S, Pfeiffer, R, Burashnikov, E et al.. ABCC9 is a novel Brugada and early repolarization syndrome susceptibility gene. Int. J. Cardiol. 2014;171 (3):431-42. doi: 10.1016/j.ijcard.2013.12.084. PubMed PMID:24439875 PubMed Central PMC3947869.
  76. Gurabi, Z, Koncz, I, Patocskai, B, Nesterenko, VV, Antzelevitch, C. Cellular mechanism underlying hypothermia-induced ventricular tachycardia/ventricular fibrillation in the setting of early repolarization and the protective effect of quinidine, cilostazol, and milrinone. Circ Arrhythm Electrophysiol. 2014;7 (1):134-42. doi: 10.1161/CIRCEP.113.000919. PubMed PMID:24429494 PubMed Central PMC3951442.
  77. Koncz, I, Gurabi, Z, Patocskai, B, Panama, BK, Szél, T, Hu, D et al.. Mechanisms underlying the development of the electrocardiographic and arrhythmic manifestations of early repolarization syndrome. J. Mol. Cell. Cardiol. 2014;68 :20-8. doi: 10.1016/j.yjmcc.2013.12.012. PubMed PMID:24378566 PubMed Central PMC3943882.
  78. Baranchuk, A, Sicouri, S, Elizari, MV, Chiale, PA. Pause-dependent normalization of ST-segment elevation during the ajmaline test in a patient with Brugada syndrome. Heart Rhythm. 2014;11 (4):707-9. doi: 10.1016/j.hrthm.2013.12.022. PubMed PMID:24333924 .
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