Click below to access scholarly publications that report original empirical and theoretical work done at the Masonic Medical Research Institute.
- Gripp, KW, Schill, L, Schoyer, L, Stronach, B, Bennett, AM, Blaser, S et al.. The sixth international RASopathies symposium: Precision medicine-From promise to practice. Am. J. Med. Genet. A. 2019; :. doi: 10.1002/ajmg.a.61434. PubMed PMID:31825160 .
- Perenthaler, E, Nikoncuk, A, Yousefi, S, Berdowski, WM, Alsagob, M, Capo, I et al.. Loss of UGP2 in brain leads to a severe epileptic encephalopathy, emphasizing that bi-allelic isoform-specific start-loss mutations of essential genes can cause genetic diseases. Acta Neuropathol. 2019; :. doi: 10.1007/s00401-019-02109-6. PubMed PMID:31820119 .
- Gussak, G, Pfenniger, A, Wren, L, Gilani, M, Zhang, W, Yoo, S et al.. Region-specific parasympathetic nerve remodeling in the left atrium contributes to creation of a vulnerable substrate for atrial fibrillation. JCI Insight. 2019;4 (20):. doi: 10.1172/jci.insight.130532. PubMed PMID:31503549 PubMed Central PMC6824299.
- Treat, JA, Goodrow, RJ, Bot, CT, Haedo, RJ, Cordeiro, JM. Pharmacological enhancement of repolarization reserve in human induced pluripotent stem cells derived cardiomyocytes. Biochem. Pharmacol. 2019;169 :113608. doi: 10.1016/j.bcp.2019.08.010. PubMed PMID:31465775 .
- Pathmanathan, P, Cordeiro, JM, Gray, RA. Comprehensive Uncertainty Quantification and Sensitivity Analysis for Cardiac Action Potential Models. Front Physiol. 2019;10 :721. doi: 10.3389/fphys.2019.00721. PubMed PMID:31297060 PubMed Central PMC6607060.
- Jaffré, F, Miller, CL, Schänzer, A, Evans, T, Roberts, AE, Hahn, A et al.. Inducible Pluripotent Stem Cell-Derived Cardiomyocytes Reveal Aberrant Extracellular Regulated Kinase 5 and Mitogen-Activated Protein Kinase Kinase 1/2 Signaling Concomitantly Promote Hypertrophic Cardiomyopathy in RAF1-Associated Noonan Syndrome. Circulation. 2019;140 (3):207-224. doi: 10.1161/CIRCULATIONAHA.118.037227. PubMed PMID:31163979 PubMed Central PMC6709678.
- Yu, W, Ma, X, Xu, J, Heumüller, AW, Fei, Z, Feng, X et al.. VGLL4 plays a critical role in heart valve development and homeostasis. PLoS Genet. 2019;15 (2):e1007977. doi: 10.1371/journal.pgen.1007977. PubMed PMID:30789911 PubMed Central PMC6400400.
- Lux, JC, Channaveerappa, D, Aslebagh, R, Heintz, TA, McLerie, M, Panama, BK et al.. Identification of dysregulation of atrial proteins in rats with chronic obstructive apnea using two-dimensional polyacrylamide gel electrophoresis and mass spectrometry. J. Cell. Mol. Med. 2019;23 (4):3016-3020. doi: 10.1111/jcmm.14131. PubMed PMID:30756508 PubMed Central PMC6433690.
- Tümüklü, MN, Tümüklü, MM, Nesterenko, V, Jayathilake, K, Beasley, CM Jr, Meltzer, HY et al.. Twenty-Four-Hour Measures of Heart Rate-Corrected QT Interval, Peak-to-End of the T-Wave, and Peak-to-End of the T-Wave/Corrected QT Interval Ratio During Antipsychotic Treatment. J Clin Psychopharmacol. ;39 (2):100-107. doi: 10.1097/JCP.0000000000001003. PubMed PMID:30707117 .
- Li, R, Baskfield, A, Lin, Y, Beers, J, Zou, J, Liu, C et al.. Generation of an induced pluripotent stem cell line (TRNDi003-A) from a Noonan syndrome with multiple lentigines (NSML) patient carrying a p.Q510P mutation in the PTPN11 gene. Stem Cell Res. 2019;34 :101374. doi: 10.1016/j.scr.2018.101374. PubMed PMID:30640061 .
- Yoon, N, Patocskai, B, Antzelevitch, C. Epicardial Substrate as a Target for Radiofrequency Ablation in an Experimental Model of Early Repolarization Syndrome. Circ Arrhythm Electrophysiol. 2018;11 (9):e006511. doi: 10.1161/CIRCEP.118.006511. PubMed PMID:30354293 .
- Sicouri, S, Belardinelli, L, Antzelevitch, C. Effect of autonomic influences to induce triggered activity in muscular sleeves extending into the coronary sinus of the canine heart and its suppression by ranolazine. J. Cardiovasc. Electrophysiol. 2019;30 (2):230-238. doi: 10.1111/jce.13770. PubMed PMID:30302862 .
- Yuan, M, Tian, C, Li, X, Yang, X, Wang, X, Yang, Y et al.. Gender Differences in Prognosis and Risk Stratification of Brugada Syndrome: A Pooled Analysis of 4,140 Patients From 24 Clinical Trials. Front Physiol. 2018;9 :1127. doi: 10.3389/fphys.2018.01127. PubMed PMID:30246798 PubMed Central PMC6113678.
- Shiferaw, Y, Aistrup, GL, Wasserstrom, JA. Synchronization of Triggered Waves in Atrial Tissue. Biophys. J. 2018;115 (6):1130-1141. doi: 10.1016/j.bpj.2018.08.015. PubMed PMID:30195941 PubMed Central PMC6139957.
- Calloe, K, Aistrup, GL, Di Diego, JM, Goodrow, RJ, Treat, JA, Cordeiro, JM et al.. Interventricular differences in sodium current and its potential role in Brugada syndrome. Physiol Rep. 2018;6 (14):e13787. doi: 10.14814/phy2.13787. PubMed PMID:30009404 PubMed Central PMC6046646.
- Hu, D, Li, Y, Zhang, J, Pfeiffer, R, Gollob, MH, Healey, J et al.. The Phenotypic Spectrum of a Mutation Hotspot Responsible for the Short QT Syndrome. JACC Clin Electrophysiol. 2017;3 (7):727-743. doi: 10.1016/j.jacep.2016.11.013. PubMed PMID:29759541 .
- Xu, G, Gottschalk, BH, Anselm, DD, Benditt, DG, Maheshwari, A, Sreenivasan, S et al.. Relation of the Brugada Phenocopy to Hyperkalemia (from the International Registry on Brugada Phenocopy). Am. J. Cardiol. 2018;121 (6):715-717. doi: 10.1016/j.amjcard.2017.12.008. PubMed PMID:29397883 .
- Baker, CE, Moore-Lotridge, SN, Hysong, AA, Posey, SL, Robinette, JP, Blum, DM et al.. Bone Fracture Acute Phase Response-A Unifying Theory of Fracture Repair: Clinical and Scientific Implications. Clin Rev Bone Miner Metab. 2018;16 (4):142-158. doi: 10.1007/s12018-018-9256-x. PubMed PMID:30930699 PubMed Central PMC6404386.
- Li, Y, Zhang, Z, Xiong, X, Cho, WC, Hu, D, Gao, Y et al.. Immediate/Early vs. Delayed Invasive Strategy for Patients with Non-ST-Segment Elevation Acute Coronary Syndromes: A Systematic Review and Meta-Analysis. Front Physiol. 2017;8 :952. doi: 10.3389/fphys.2017.00952. PubMed PMID:29230180 PubMed Central PMC5712112.
- Shi, S, Barajas-Martinez, H, Liu, T, Sun, Y, Yang, B, Huang, C et al.. Prevalence of spontaneous Brugada ECG pattern recorded at standard intercostal leads: A meta-analysis. Int. J. Cardiol. 2018;254 :151-156. doi: 10.1016/j.ijcard.2017.11.113. PubMed PMID:29224924 .
- Goodrow, RJ Jr, Desai, S, Treat, JA, Panama, BK, Desai, M, Nesterenko, VV et al.. Biophysical comparison of sodium currents in native cardiac myocytes and human induced pluripotent stem cell-derived cardiomyocytes. J Pharmacol Toxicol Methods. ;90 :19-30. doi: 10.1016/j.vascn.2017.11.001. PubMed PMID:29128504 .
- Aistrup, GL, Arora, R, Grubb, S, Yoo, S, Toren, B, Kumar, M et al.. Triggered intracellular calcium waves in dog and human left atrial myocytes from normal and failing hearts. Cardiovasc. Res. 2017;113 (13):1688-1699. doi: 10.1093/cvr/cvx167. PubMed PMID:29016724 PubMed Central PMC5852523.
- Patocskai, B, Yoon, N, Antzelevitch, C. Mechanisms Underlying Epicardial Radiofrequency Ablation to Suppress Arrhythmogenesis in Experimental Models of Brugada Syndrome. JACC Clin Electrophysiol. 2017;3 (4):353-363. doi: 10.1016/j.jacep.2016.10.011. PubMed PMID:28948234 PubMed Central PMC5609479.
- Li, J, Li, Y, Zhang, Y, Hu, D, Gao, Y, Shang, H et al.. The Inhibitory Effect of WenxinKeli on H9C2 Cardiomyocytes Hypertrophy Induced by Angiotensin II through Regulating Autophagy Activity. Oxid Med Cell Longev. 2017;2017 :7042872. doi: 10.1155/2017/7042872. PubMed PMID:28713489 PubMed Central PMC5496123.
- Wang, X, Hu, D, Dang, S, Huang, H, Huang, CX, Yuan, MJ et al.. Effects of Traditional Chinese Medicine Shensong Yangxin Capsules on Heart Rhythm and Function in Congestive Heart Failure Patients with Frequent Ventricular Premature Complexes: A Randomized, Double-blind, Multicenter Clinical Trial. Chin. Med. J. 2017;130 (14):1639-1647. doi: 10.4103/0366-6999.209906. PubMed PMID:28685712 PubMed Central PMC5520549.
- Makarawate, P, Chaosuwannakit, N, Vannaprasaht, S, Sahasthas, D, Koo, SH, Lee, EJD et al.. SCN5A Genetic Polymorphisms Associated With Increased Defibrillator Shocks in Brugada Syndrome. J Am Heart Assoc. 2017;6 (6):. doi: 10.1161/JAHA.116.005009. PubMed PMID:28584071 PubMed Central PMC5669154.
- Li, J, Hu, D, Song, X, Han, T, Gao, Y, Xing, Y et al.. The Role of Biologically Active Ingredients from Natural Drug Treatments for Arrhythmias in Different Mechanisms. Biomed Res Int. 2017;2017 :4615727. doi: 10.1155/2017/4615727. PubMed PMID:28497050 PubMed Central PMC5405360.
- Shi, S, Liu, T, Barajas-Martinez, H, Pfeiffer, R, Jiang, H, Huang, C et al.. Atrial fibrillation associated with Wolff-Parkinson-White syndrome in a patient with concomitant Brugada syndrome. HeartRhythm Case Rep. 2017;3 (1):13-17. doi: 10.1016/j.hrcr.2016.12.001. PubMed PMID:28491758 PubMed Central PMC5420038.
- Chen, Y, Barajas-Martinez, H, Zhu, D, Wang, X, Chen, C, Zhuang, R et al.. Erratum to: Novel trigenic CACNA1C/DES/MYPN mutations in a family of hypertrophic cardiomyopathy with early repolarization and short QT syndrome. J Transl Med. 2017;15 (1):101. doi: 10.1186/s12967-017-1203-y. PubMed PMID:28490369 PubMed Central PMC5425985.
- Chen, Y, Barajas-Martinez, H, Zhu, D, Wang, X, Chen, C, Zhuang, R et al.. Novel trigenic CACNA1C/DES/MYPN mutations in a family of hypertrophic cardiomyopathy with early repolarization and short QT syndrome. J Transl Med. 2017;15 (1):78. doi: 10.1186/s12967-017-1180-1. PubMed PMID:28427417 PubMed Central PMC5399316.
- Channaveerappa, D, Lux, JC, Wormwood, KL, Heintz, TA, McLerie, M, Treat, JA et al.. Atrial electrophysiological and molecular remodelling induced by obstructive sleep apnoea. J. Cell. Mol. Med. 2017;21 (9):2223-2235. doi: 10.1111/jcmm.13145. PubMed PMID:28402037 PubMed Central PMC5571519.
- Yu, L, Wang, M, Hu, D, Huang, B, Zhou, L, Zhou, X et al.. Blocking the Nav1.8 channel in the left stellate ganglion suppresses ventricular arrhythmia induced by acute ischemia in a canine model. Sci Rep. 2017;7 (1):534. doi: 10.1038/s41598-017-00642-6. PubMed PMID:28373696 PubMed Central PMC5428783.
- Barajas-Martinez, H, Goodrow, RJ, Hu, D, Patel, P, Desai, M, Panama, BK et al.. Biophysical and molecular comparison of sodium current in cells isolated from canine atria and pulmonary vein. Pflugers Arch. 2017;469 (5-6):703-712. doi: 10.1007/s00424-017-1956-4. PubMed PMID:28243733 .
- Feng, Y, Liu, J, Wang, M, Liu, M, Shi, L, Yuan, W et al.. The E23K variant of the Kir6.2 subunit of the ATP-sensitive potassium channel increases susceptibility to ventricular arrhythmia in response to ischemia in rats. Int. J. Cardiol. 2017;232 :192-198. doi: 10.1016/j.ijcard.2017.01.022. PubMed PMID:28082085 .
- Chen, X, Yu, L, Shi, S, Jiang, H, Huang, C, Desai, M et al.. Neuronal Nav1.8 Channels as a Novel Therapeutic Target of Acute Atrial Fibrillation Prevention. J Am Heart Assoc. 2016;5 (11):. doi: 10.1161/JAHA.116.004050. PubMed PMID:27806967 PubMed Central PMC5210368.
- Dai, M, Bao, M, Zhang, Y, Yu, L, Cao, Q, Tang, Y et al.. Low-level carotid baroreflex stimulation suppresses atrial fibrillation by inhibiting left stellate ganglion activity in an acute canine model. Heart Rhythm. 2016;13 (11):2203-2212. doi: 10.1016/j.hrthm.2016.08.021. PubMed PMID:27520541 .
- Chorin, E, Hu, D, Antzelevitch, C, Hochstadt, A, Belardinelli, L, Zeltser, D et al.. Ranolazine for Congenital Long-QT Syndrome Type III: Experimental and Long-Term Clinical Data. Circ Arrhythm Electrophysiol. 2016;9 (10):. doi: 10.1161/CIRCEP.116.004370. PubMed PMID:27733495 PubMed Central PMC5119553.
- Yang, M, Zhang, GG, Wang, T, Wang, X, Tang, YH, Huang, H et al.. TBX18 gene induces adipose-derived stem cells to differentiate into pacemaker-like cells in the myocardial microenvironment. Int. J. Mol. Med. 2016;38 (5):1403-1410. doi: 10.3892/ijmm.2016.2736. PubMed PMID:27632938 PubMed Central PMC5065308.
- Shi, S, Liu, T, Liang, J, Hu, D, Yang, B. Depression and Risk of Sudden Cardiac Death and Arrhythmias: A Meta-Analysis. Psychosom Med. ;79 (2):153-161. doi: 10.1097/PSY.0000000000000382. PubMed PMID:27627224 .
- Huang, Y, Wang, D, Wang, X, Zhang, Y, Liu, T, Chen, Y et al.. Abrogation of CC chemokine receptor 9 ameliorates ventricular remodeling in mice after myocardial infarction. Sci Rep. 2016;6 :32660. doi: 10.1038/srep32660. PubMed PMID:27585634 PubMed Central PMC5009347.
- Veltmann, C, Barajas-Martinez, H, Wolpert, C, Borggrefe, M, Schimpf, R, Pfeiffer, R et al.. Further Insights in the Most Common SCN5A Mutation Causing Overlapping Phenotype of Long QT Syndrome, Brugada Syndrome, and Conduction Defect. J Am Heart Assoc. 2016;5 (7):. doi: 10.1161/JAHA.116.003379. PubMed PMID:27381756 PubMed Central PMC5015375.
- Sutphin, BS, Boczek, NJ, Barajas-Martínez, H, Hu, D, Ye, D, Tester, DJ et al.. Molecular and Functional Characterization of Rare CACNA1C Variants in Sudden Unexplained Death in the Young. Congenit Heart Dis. 2016;11 (6):683-692. doi: 10.1111/chd.12371. PubMed PMID:27218670 .
- Shi, S, Liu, T, Wang, D, Zhang, Y, Liang, J, Yang, B et al.. Activation of N-methyl-d-aspartate receptors reduces heart rate variability and facilitates atrial fibrillation in rats. Europace. 2017;19 (7):1237-1243. doi: 10.1093/europace/euw086. PubMed PMID:27170002 .
- Mizusawa, Y, Morita, H, Adler, A, Havakuk, O, Thollet, A, Maury, P et al.. Prognostic significance of fever-induced Brugada syndrome. Heart Rhythm. 2016;13 (7):1515-20. doi: 10.1016/j.hrthm.2016.03.044. PubMed PMID:27033637 .
- Calloe, K, Di Diego, JM, Hansen, RS, Nagle, SA, Treat, JA, Cordeiro, JM et al.. A dual potassium channel activator improves repolarization reserve and normalizes ventricular action potentials. Biochem. Pharmacol. 2016;108 :36-46. doi: 10.1016/j.bcp.2016.03.015. PubMed PMID:27002181 .
- Wang, D, Liu, T, Shi, S, Li, R, Shan, Y, Huang, Y et al.. Chronic Administration of Catestatin Improves Autonomic Function and Exerts Cardioprotective Effects in Myocardial Infarction Rats. J. Cardiovasc. Pharmacol. Ther. 2016;21 (6):526-535. doi: 10.1177/1074248416628676. PubMed PMID:26821570 .
- Patocskai, B, Barajas-Martinez, H, Hu, D, Gurabi, Z, Koncz, I, Antzelevitch, C et al.. Cellular and ionic mechanisms underlying the effects of cilostazol, milrinone, and isoproterenol to suppress arrhythmogenesis in an experimental model of early repolarization syndrome. Heart Rhythm. 2016;13 (6):1326-34. doi: 10.1016/j.hrthm.2016.01.024. PubMed PMID:26820510 PubMed Central PMC4879023.
- Hu, D, Barajas-Martínez, H, Burashnikov, A, Panama, BK, Cordeiro, JM, Antzelevitch, C et al.. Mechanisms underlying atrial-selective block of sodium channels by Wenxin Keli: Experimental and theoretical analysis. Int. J. Cardiol. 2016;207 :326-34. doi: 10.1016/j.ijcard.2016.01.016. PubMed PMID:26820362 PubMed Central PMC4758862.
- Panama, BK, Korogyi, AS, Aschar-Sobbi, R, Oh, Y, Gray, CB, Gang, H et al.. Reductions in the Cardiac Transient Outward K+ Current Ito Caused by Chronic β-Adrenergic Receptor Stimulation Are Partly Rescued by Inhibition of Nuclear Factor κB. J. Biol. Chem. 2016;291 (8):4156-65. doi: 10.1074/jbc.M115.694984. PubMed PMID:26742842 PubMed Central PMC4759190.
- Cordeiro, JM, Calloe, K, Aschar-Sobbi, R, Kim, KH, Korogyi, A, Occhipinti, D et al.. Physiological roles of the transient outward current Ito in normal and diseased hearts. Front Biosci (Schol Ed). 2016;8 :143-59. doi: 10.2741/s454. PubMed PMID:26709904 .
- Xing, Y, Hu, D, Zhang, T, Antzelevitch, C. Traditional Chinese Medicine and Vascular Disease. Evid Based Complement Alternat Med. 2015;2015 :430818. doi: 10.1155/2015/430818. PubMed PMID:26576194 PubMed Central PMC4631889.
- Hasdemir, C, Payzin, S, Kocabas, U, Sahin, H, Yildirim, N, Alp, A et al.. High prevalence of concealed Brugada syndrome in patients with atrioventricular nodal reentrant tachycardia. Heart Rhythm. 2015;12 (7):1584-94. doi: 10.1016/j.hrthm.2015.03.015. PubMed PMID:25998140 .
- Cordeiro, JM, Zeina, T, Goodrow, R, Kaplan, AD, Thomas, LM, Nesterenko, VV et al.. Regional variation of the inwardly rectifying potassium current in the canine heart and the contributions to differences in action potential repolarization. J. Mol. Cell. Cardiol. 2015;84 :52-60. doi: 10.1016/j.yjmcc.2015.04.010. PubMed PMID:25889894 PubMed Central PMC4468020.
- Giustetto, C, Scrocco, C, Schimpf, R, Maury, P, Mazzanti, A, Levetto, M et al.. Usefulness of exercise test in the diagnosis of short QT syndrome. Europace. 2015;17 (4):628-34. doi: 10.1093/europace/euu351. PubMed PMID:25833882 .
- Tan, BY, Yong, RY, Barajas-Martinez, H, Dumaine, R, Chew, YX, Wasan, PS et al.. A Brugada syndrome proband with compound heterozygote SCN5A mutations identified from a Chinese family in Singapore. Europace. 2016;18 (6):897-904. doi: 10.1093/europace/euv058. PubMed PMID:25829473 .
- Liang, J, Yuan, X, Shi, S, Wang, F, Chen, Y, Qu, C et al.. Effect and mechanism of fluoxetine on electrophysiology in vivo in a rat model of postmyocardial infarction depression. Drug Des Devel Ther. 2015;9 :763-72. doi: 10.2147/DDDT.S75863. PubMed PMID:25709400 PubMed Central PMC4330040.
- Obeyesekere, MN, Antzelevitch, C, Krahn, AD. Management of ventricular arrhythmias in suspected channelopathies. Circ Arrhythm Electrophysiol. 2015;8 (1):221-31. doi: 10.1161/CIRCEP.114.002321. PubMed PMID:25691556 .
- Pathmanathan, P, Shotwell, MS, Gavaghan, DJ, Cordeiro, JM, Gray, RA. Uncertainty quantification of fast sodium current steady-state inactivation for multi-scale models of cardiac electrophysiology. Prog. Biophys. Mol. Biol. 2015;117 (1):4-18. doi: 10.1016/j.pbiomolbio.2015.01.008. PubMed PMID:25661325 PubMed Central PMC4472478.
- Burashnikov, A, Di Diego, JM, Goodrow, RJ Jr, Belardinelli, L, Antzelevitch, C. Atria are More Sensitive Than Ventricles to GS-458967-Induced Inhibition of Late Sodium Current. J. Cardiovasc. Pharmacol. Ther. 2015;20 (5):501-8. doi: 10.1177/1074248415570636. PubMed PMID:25652294 .
- Burashnikov, A, Belardinelli, L, Antzelevitch, C. Inhibition of IKr potentiates development of atrial-selective INa block leading to effective suppression of atrial fibrillation. Heart Rhythm. 2015;12 (4):836-44. doi: 10.1016/j.hrthm.2014.12.033. PubMed PMID:25546810 .
- Maleckar, MM, Lines, GT, Koivumäki, JT, Cordeiro, JM, Calloe, K. NS5806 partially restores action potential duration but fails to ameliorate calcium transient dysfunction in a computational model of canine heart failure. Europace. 2014;16 Suppl 4 :iv46-iv55. doi: 10.1093/europace/euu252. PubMed PMID:25362170 .
- Boczek, NJ, Miller, EM, Ye, D, Nesterenko, VV, Tester, DJ, Antzelevitch, C et al.. Novel Timothy syndrome mutation leading to increase in CACNA1C window current. Heart Rhythm. 2015;12 (1):211-9. doi: 10.1016/j.hrthm.2014.09.051. PubMed PMID:25260352 PubMed Central PMC4907369.
- Hennessey, JA, Boczek, NJ, Jiang, YH, Miller, JD, Patrick, W, Pfeiffer, R et al.. A CACNA1C variant associated with reduced voltage-dependent inactivation, increased CaV1.2 channel window current, and arrhythmogenesis. PLoS ONE. 2014;9 (9):e106982. doi: 10.1371/journal.pone.0106982. PubMed PMID:25184293 PubMed Central PMC4153713.
- Shi, S, Liang, J, Liu, T, Yuan, X, Ruan, B, Sun, L et al.. Depression increases sympathetic activity and exacerbates myocardial remodeling after myocardial infarction: evidence from an animal experiment. PLoS ONE. 2014;9 (7):e101734. doi: 10.1371/journal.pone.0101734. PubMed PMID:25036781 PubMed Central PMC4103791.
- Hu, D, Barajas-Martínez, H, Pfeiffer, R, Dezi, F, Pfeiffer, J, Buch, T et al.. Mutations in SCN10A are responsible for a large fraction of cases of Brugada syndrome. J. Am. Coll. Cardiol. 2014;64 (1):66-79. doi: 10.1016/j.jacc.2014.04.032. PubMed PMID:24998131 PubMed Central PMC4116276.
- Burashnikov, A, Di Diego, JM, Barajas-Martínez, H, Hu, D, Zygmunt, AC, Cordeiro, JM et al.. Ranolazine effectively suppresses atrial fibrillation in the setting of heart failure. Circ Heart Fail. 2014;7 (4):627-33. doi: 10.1161/CIRCHEARTFAILURE.114.001129. PubMed PMID:24874201 PubMed Central PMC4102661.
- Tülümen, E, Giustetto, C, Wolpert, C, Maury, P, Anttonen, O, Probst, V et al.. Reply to the Editor--PQ-segment depression in short QT syndrome patients: a novel marker for diagnosing short QT syndrome?. Heart Rhythm. 2014;11 (7):e8. doi: 10.1016/j.hrthm.2014.04.028. PubMed PMID:24768854 .
- Di Diego, JM, Antzelevitch, C. Acute myocardial ischemia: cellular mechanisms underlying ST segment elevation. J Electrocardiol. ;47 (4):486-90. doi: 10.1016/j.jelectrocard.2014.02.005. PubMed PMID:24742586 PubMed Central PMC4116460.
- Antzelevitch, C, Nesterenko, V, Shryock, JC, Rajamani, S, Song, Y, Belardinelli, L et al.. The role of late I Na in development of cardiac arrhythmias. Handb Exp Pharmacol. 2014;221 :137-68. doi: 10.1007/978-3-642-41588-3_7. PubMed PMID:24737235 PubMed Central PMC4076160.
- Szél, T, Antzelevitch, C. Abnormal repolarization as the basis for late potentials and fractionated electrograms recorded from epicardium in experimental models of Brugada syndrome. J. Am. Coll. Cardiol. 2014;63 (19):2037-45. doi: 10.1016/j.jacc.2014.01.067. PubMed PMID:24657694 PubMed Central PMC4024366.
- Tülümen, E, Giustetto, C, Wolpert, C, Maury, P, Anttonen, O, Probst, V et al.. PQ segment depression in patients with short QT syndrome: a novel marker for diagnosing short QT syndrome?. Heart Rhythm. 2014;11 (6):1024-30. doi: 10.1016/j.hrthm.2014.02.024. PubMed PMID:24589867 PubMed Central PMC4108989.
- Burashnikov, A, Di Diego, JM, Sicouri, S, Doss, MX, Sachinidis, A, Barajas-Martínez, H et al.. A temporal window of vulnerability for development of atrial fibrillation with advancing heart failure. Eur. J. Heart Fail. 2014;16 (3):271-80. doi: 10.1002/ejhf.28. PubMed PMID:24464846 .
- Hu, D, Barajas-Martínez, H, Terzic, A, Park, S, Pfeiffer, R, Burashnikov, E et al.. ABCC9 is a novel Brugada and early repolarization syndrome susceptibility gene. Int. J. Cardiol. 2014;171 (3):431-42. doi: 10.1016/j.ijcard.2013.12.084. PubMed PMID:24439875 PubMed Central PMC3947869.
- Gurabi, Z, Koncz, I, Patocskai, B, Nesterenko, VV, Antzelevitch, C. Cellular mechanism underlying hypothermia-induced ventricular tachycardia/ventricular fibrillation in the setting of early repolarization and the protective effect of quinidine, cilostazol, and milrinone. Circ Arrhythm Electrophysiol. 2014;7 (1):134-42. doi: 10.1161/CIRCEP.113.000919. PubMed PMID:24429494 PubMed Central PMC3951442.
- Koncz, I, Gurabi, Z, Patocskai, B, Panama, BK, Szél, T, Hu, D et al.. Mechanisms underlying the development of the electrocardiographic and arrhythmic manifestations of early repolarization syndrome. J. Mol. Cell. Cardiol. 2014;68 :20-8. doi: 10.1016/j.yjmcc.2013.12.012. PubMed PMID:24378566 PubMed Central PMC3943882.
- Baranchuk, A, Sicouri, S, Elizari, MV, Chiale, PA. Pause-dependent normalization of ST-segment elevation during the ajmaline test in a patient with Brugada syndrome. Heart Rhythm. 2014;11 (4):707-9. doi: 10.1016/j.hrthm.2013.12.022. PubMed PMID:24333924 .
- Barajas-Martínez, H, Hu, D, Antzelevitch, C. [Genetic and molecular basis for sodium channel-mediated Brugada syndrome]. Arch Cardiol Mex. ;83 (4):295-302. doi: 10.1016/j.acmx.2013.10.001. PubMed PMID:24269159 .
- Barajas-Martínez, H, Hu, D, Goodrow, RJ Jr, Joyce, F, Antzelevitch, C. Electrophysiologic characteristics and pharmacologic response of human cardiomyocytes isolated from a patient with hypertrophic cardiomyopathy. Pacing Clin Electrophysiol. 2013;36 (12):1512-5. doi: 10.1111/pace.12227. PubMed PMID:24117780 PubMed Central PMC3855624.
- Cordeiro, JM, Panama, BK, Goodrow, R, Zygmunt, AC, White, C, Treat, JA et al.. Developmental changes in expression and biophysics of ion channels in the canine ventricle. J. Mol. Cell. Cardiol. 2013;64 :79-89. doi: 10.1016/j.yjmcc.2013.09.001. PubMed PMID:24035801 PubMed Central PMC3837711.
- Antzelevitch, C. J wave syndromes: molecular and cellular mechanisms. J Electrocardiol. ;46 (6):510-8. doi: 10.1016/j.jelectrocard.2013.08.006. PubMed PMID:24011992 PubMed Central PMC3825797.
- Szél, T, Koncz, I, Antzelevitch, C. Cellular mechanisms underlying the effects of milrinone and cilostazol to suppress arrhythmogenesis associated with Brugada syndrome. Heart Rhythm. 2013;10 (11):1720-7. doi: 10.1016/j.hrthm.2013.07.047. PubMed PMID:23911896 PubMed Central PMC3825770.
- Cordeiro, JM, Nesterenko, VV, Sicouri, S, Goodrow, RJ Jr, Treat, JA, Desai, M et al.. Identification and characterization of a transient outward K+ current in human induced pluripotent stem cell-derived cardiomyocytes. J. Mol. Cell. Cardiol. 2013;60 :36-46. doi: 10.1016/j.yjmcc.2013.03.014. PubMed PMID:23542310 PubMed Central PMC3779808.
- Sicouri, S, Belardinelli, L, Antzelevitch, C. Antiarrhythmic effects of the highly selective late sodium channel current blocker GS-458967. Heart Rhythm. 2013;10 (7):1036-43. doi: 10.1016/j.hrthm.2013.03.023. PubMed PMID:23524321 PubMed Central PMC3836836.
- Minoura, Y, Panama, BK, Nesterenko, VV, Betzenhauser, M, Barajas-Martínez, H, Hu, D et al.. Effect of Wenxin Keli and quinidine to suppress arrhythmogenesis in an experimental model of Brugada syndrome. Heart Rhythm. 2013;10 (7):1054-62. doi: 10.1016/j.hrthm.2013.03.011. PubMed PMID:23499631 PubMed Central PMC3702731.
- Pérez, GJ, Desai, M, Anderson, S, Scornik, FS. Large-conductance calcium-activated potassium current modulates excitability in isolated canine intracardiac neurons. Am. J. Physiol., Cell Physiol. 2013;304 (3):C280-6. doi: 10.1152/ajpcell.00148.2012. PubMed PMID:23195072 PubMed Central PMC3566438.
- Di Diego, JM, Sicouri, S, Myles, RC, Burton, FL, Smith, GL, Antzelevitch, C et al.. Optical and electrical recordings from isolated coronary-perfused ventricular wedge preparations. J. Mol. Cell. Cardiol. 2013;54 :53-64. doi: 10.1016/j.yjmcc.2012.10.017. PubMed PMID:23142540 PubMed Central PMC3535682.
- Burashnikov, A, Antzelevitch, C. Role of late sodium channel current block in the management of atrial fibrillation. Cardiovasc Drugs Ther. 2013;27 (1):79-89. doi: 10.1007/s10557-012-6421-1. PubMed PMID:23108433 PubMed Central PMC3557765.
- Doss, MX, Di Diego, JM, Goodrow, RJ, Wu, Y, Cordeiro, JM, Nesterenko, VV et al.. Maximum diastolic potential of human induced pluripotent stem cell-derived cardiomyocytes depends critically on I(Kr). PLoS ONE. 2012;7 (7):e40288. doi: 10.1371/journal.pone.0040288. PubMed PMID:22815737 PubMed Central PMC3396384.
- Antzelevitch, C. Genetic, molecular and cellular mechanisms underlying the J wave syndromes. Circ. J. 2012;76 (5):1054-65. doi: 10.1253/circj.cj-12-0284. PubMed PMID:22498570 PubMed Central PMC3521574.
- Cordeiro, JM, Calloe, K, Moise, NS, Kornreich, B, Giannandrea, D, Di Diego, JM et al.. Physiological consequences of transient outward K+ current activation during heart failure in the canine left ventricle. J. Mol. Cell. Cardiol. 2012;52 (6):1291-8. doi: 10.1016/j.yjmcc.2012.03.001. PubMed PMID:22434032 PubMed Central PMC3401930.
- Sicouri, S, Blazek, J, Belardinelli, L, Antzelevitch, C. Electrophysiological characteristics of canine superior vena cava sleeve preparations: effect of ranolazine. Circ Arrhythm Electrophysiol. 2012;5 (2):371-9. doi: 10.1161/CIRCEP.111.969493. PubMed PMID:22407414 PubMed Central PMC3329588.
- Burashnikov, A, Barajas-Martinez, H, Hu, D, Nof, E, Blazek, J, Antzelevitch, C et al.. Atrial-selective prolongation of refractory period with AVE0118 is due principally to inhibition of sodium channel activity. J. Cardiovasc. Pharmacol. 2012;59 (6):539-46. doi: 10.1097/FJC.0b013e31824e1b93. PubMed PMID:22370957 PubMed Central PMC3369013.
- Burashnikov, A, Pourrier, M, Gibson, JK, Lynch, JJ, Antzelevitch, C. Rate-dependent effects of vernakalant in the isolated non-remodeled canine left atria are primarily due to block of the sodium channel: comparison with ranolazine and dl-sotalol. Circ Arrhythm Electrophysiol. 2012;5 (2):400-8. doi: 10.1161/CIRCEP.111.968305. PubMed PMID:22322366 PubMed Central PMC3329593.
- Hu, D, Barajas-Martínez, H, Medeiros-Domingo, A, Crotti, L, Veltmann, C, Schimpf, R et al.. A novel rare variant in SCN1Bb linked to Brugada syndrome and SIDS by combined modulation of Na(v)1.5 and K(v)4.3 channel currents. Heart Rhythm. 2012;9 (5):760-9. doi: 10.1016/j.hrthm.2011.12.006. PubMed PMID:22155597 PubMed Central PMC3334446.
- Barajas-Martínez, H, Hu, D, Ferrer, T, Onetti, CG, Wu, Y, Burashnikov, E et al.. Molecular genetic and functional association of Brugada and early repolarization syndromes with S422L missense mutation in KCNJ8. Heart Rhythm. 2012;9 (4):548-55. doi: 10.1016/j.hrthm.2011.10.035. PubMed PMID:22056721 PubMed Central PMC3288170.
- Burashnikov, A, Antzelevitch, C. Ranolazine versus amiodarone for prevention of postoperative atrial fibrillation. Future Cardiol. 2011;7 (6):733-7. doi: 10.2217/fca.11.67. PubMed PMID:22050058 PubMed Central PMC4737707.
- Minoura, Y, Di Diego, JM, Barajas-Martínez, H, Zygmunt, AC, Hu, D, Sicouri, S et al.. Ionic and cellular mechanisms underlying the development of acquired Brugada syndrome in patients treated with antidepressants. J. Cardiovasc. Electrophysiol. 2012;23 (4):423-32. doi: 10.1111/j.1540-8167.2011.02196.x. PubMed PMID:22034916 PubMed Central PMC3468832.
- Sicouri, S, Pourrier, M, Gibson, JK, Lynch, JJ, Antzelevitch, C. Comparison of electrophysiological and antiarrhythmic effects of vernakalant, ranolazine, and sotalol in canine pulmonary vein sleeve preparations. Heart Rhythm. 2012;9 (3):422-9. doi: 10.1016/j.hrthm.2011.10.021. PubMed PMID:22019863 PubMed Central PMC3288874.
- Burashnikov, A, Belardinelli, L, Antzelevitch, C. Atrial-selective sodium channel block strategy to suppress atrial fibrillation: ranolazine versus propafenone. J. Pharmacol. Exp. Ther. 2012;340 (1):161-8. doi: 10.1124/jpet.111.186395. PubMed PMID:22005044 PubMed Central PMC3251016.
- Antzelevitch, C, Yan, GX. J-wave syndromes. from cell to bedside. J Electrocardiol. ;44 (6):656-61. doi: 10.1016/j.jelectrocard.2011.07.026. PubMed PMID:21908004 PubMed Central PMC3200490.